ZIS 150 Complete Kit

[Mustang46555]

Yes, I think it's very doable.
I've seen the same style transmission listed on evil bay with a forward facing output or a transfer case mounted where the current carrier bearing is located will take care of drive and one of the metal front axles should bolt right on. Being 1/12 scale there is a bit more room under the truck so I don't see any conversion issues. King Kong sells ZIS 151 tires which are a bit wider but with a more aggressive tread. But be sure you find a 2mm socket, it is vital to proper assembly of both the chassis and the bed.